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| Registros recuperados: 12 | |
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| Diniz,Simone Odília Fernandes; Barbosa,Alfredo José Afonso; Araújo,Ivana Durval; Nelson,David Lee; Machado,Leonardo Augusto da Silva; Bernardo Filho,Mário; Cardoso,Valbert Nascimento. |
| In obstructive jaundice, the passage of bacteria and endotoxins through the intestine wall to reach the systemic circulation is associated with septicemia, renal failure and pulmonary dysfunction. The aim of this work was to investigate bacterial translocation utilizing 99mTc-E.coli in an experimental model of obstructive jaundice. The levels of bilirubin in rats that were subjected to ligature of the bile duct were significantly increased when compared to control animals (p < 0.001). The biodistribution results did not show any translocation of 99mTc-E.coli to the mesenteric lymphatic nodules, liver, spleen or lungs of the rats that suffered ligature of the bile duct (p > 0.05). The evaluation of the intestinal permeability using "per os"... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bacterial translocation; Technetium-99m E coli; Obstructive jaundice. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700006 |
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| Alves,Andrea Catão; Gontijo,Cristiano Machado; Oliveira,Mônica Cristina; Diniz,Simone Odília Fernandes; Oliveira,Flávia Márcia; Cardoso,Valbert Nascimento; Ramaldes,Gilson Andrade. |
| The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Liposomes; Oral absorption; Mucosal delivery; Proteins; Nanotechnology. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035 |
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| Bernardo-Filho,Mario; Santos-Filho,Sebastião David; Moura,Egberto Gaspar de; Maiworm,Adalgisa Ieda; Orlando,Margarida Maria de Camões; Penas,Maria Expósito; Cardoso,Valbert Nascimento; Bernardo,Luciana Camargo; Brito,Lavínia de Carvalho. |
| Clinical images are worthwhile in Health Sciences and their analysis and correct interpretation aid the professionals,such as physicians, physiotherapists and occupational therapists, to make decisions and take subsequent therapeutic and/or rehabilitation measures. Other factors, besides the state of the disease, may interfere and affect the bioavailability of the radiopharmaceuticals (radiobiocomplexes) and the quality of the SPECT and PET images. Furthermore, the labeling of some of these radiobiocomplexes, such as plasma proteins, white blood cells and red blood cells, with 99mT, can also be modified. These factors include drugs (synthetic and natural) and dietary conditions, as well as some medical procedures (invasive or non-invasive), such as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drug interaction; Blood constituents; Radiobiocomplexes; Bioavailability. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700003 |
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| Prado,Guilherme; Carvalho,Eliana Pinheiro de; Madeira,Jovita Eugênia Gazzinelli Cruz; Morais,Vanessa Andréa Drummond; Oliveira,Marize Silva de; Corrêa,Ricardo Ferracini; Cardoso,Valbert Nascimento. |
| Foi verificado o efeito da irradiação gama (60Co) na capacidade de destruir a microbiota fúngica, em amendoim em grão, cultivar Tatu Vermelho, da safra 2003 (segundo semestre). Os grãos de amendoim, após a irradiação, foram mantidos à temperatura ambiente em embalagem plástica comercial, durante 180 dias. Para a determinação da porcentagem fúngica foi utilizada a técnica do plaqueamento direto utilizando o meio Ágar Dicloran Rosa de Bengala Cloranfenicol (DRBC), desinfetando ou não os grãos com solução de hipoclorito de sódio. Em grãos de amendoim irradiados e desinfetados externamente, observou-se redução da infecção fúngica a 5 kGy e destruição total de fungos a 10 kGy, após 180 dias de armazenamento à temperatura ambiente. Em grãos irradiados e não... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Irradiação gama; Aflatoxina B1; Amendoim; Arachis hypogaea. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542006000500016 |
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| Prado,Guilherme; Carvalho,Eliana Pinheiro de; Oliveira,Marize Silva; Madeira,Jovita Gazzinelli Cruz; Morais,Vanessa Drummond; Correa,Ricardo Ferracini; Cardoso,Valbert Nascimento; Soares,Thaís Veloso; Silva,Juliana Fonseca Moreira da; Gonçalves,Rúbia Carolina Pereira. |
| The effect of gamma irradiation on aflatoxin B1 levels and fungal infection were investigated in peanut samples, Tatu Vermelho cultivar. At a radiation dose of 10 KGy, growth of molds was completely inhibited. Doses of 15, 20, 25 and 30 KGy were sufficient for destruction of aflatoxin B1 by 55-74%. The results suggested that the decontamination of molds by irradiation, before production of aflatoxin B1, is the most acceptable method in the preservation of peanut. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Peanut; Gamma irradiation; Aflatoxin B1. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000500047 |
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| Martin-Comin,Joseph; Cardoso,Valbert Nascimento; Plaza,Pedro; Roca,Manoel. |
| In this work Hank's balanced salt solution (HBSS) has been used, as resuspension medium, instead of leukocyte poor plasma (LPP) to label autologous white blood cells in 28 patients with suspicion af active inflammatory bowel disease.Labelled cells were reinjected and anterior and caudo-craneal views were obtained at 30 min, 2 h and 6 h p.i. Regions of interest were outlined on liver, spleen, lung, bone marrow (spine), background and lesions and the organ/background activity ratios were calculated in all scans. Patients were classified into 2 groups: Group 1: LPP, 30 patients and Groups 2: HBSS, 28 patients. Labelling efficiency was higher in HBBS group (89.0 ± 3.2 %) than in the LPP group (6.5 ± 6.3%). Organ/background activity ratios were similar in both... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 99mTechnetium; Leukocytes; Hank' s solution; Inflammatory. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500006 |
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| Arribada,Raquel Gregorio; Pereira,Nara Caroline; Cardoso,Valbert Nascimento; Cunha Júnior,Armando da Silva; Barros,André Luís Branco de. |
| Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cidofovir; Radiotracer; Technetium-99m; Biodistribution; Scintigraphic imaging. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100570 |
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| Fuscaldi,Leonardo Lima; Santos,Daniel Moreira dos; Pinheiro,Natália Gabriela Silva; Araújo,Raquel Silva; Barros,André Luís Branco de; Resende,Jarbas Magalhães; Fernandes,Simone Odília Antunes; Lima,Maria Elena de; Cardoso,Valbert Nascimento. |
| Abstract Background Current diagnostic methods and imaging techniques are not able to differentiate septic and aseptic inflammation. Thus, reliable methods are sought to provide this distinction and scintigraphic imaging is an interesting option, since it is based on physiological changes. In this context, radiolabeled antimicrobial peptides have been investigated as they accumulate in infectious sites instead of aseptic inflammation. The peptide LyeTx I, from the venom of Lycosa erythrognatha, has potent antimicrobial activity. Therefore, this study aimed to synthesize LyeTx I derivatives with the chelating compound HYNIC, to evaluate their antimicrobial activity and to radiolabel them with 99mTc. Methods Two LyeTx I derivatives, HYNIC-LyeTx I... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Septic and aseptic inflammation; Differential diagnosis; Antimicrobial peptides LyeTx I derivatives; MALDI-ToF-MS RP-HPLC; Technetium-99m; HYNIC EDDA Tricine. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100312 |
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| Carvalho Júnior,Álvaro Dutra de; Abrantes,Fabiana Moreira; Menezes,Maria Ângela; Leal,Alexandre Soares; Cardoso,Valbert Nascimento; Oliveira,Mônica Cristina de. |
| This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Radiolabelled cisplatin; Biodistribution; TRIGA research reactor. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700013 |
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| Registros recuperados: 12 | |
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